Autosomal Dominant Nonsyndromic Hearing Loss Genes

Locus (OMIM) Gene (OMIM) Key Reference (PubMed)
DFNA1 DIAPH1 Lynch et al., 1997
DFNA2A KCNQ4 Kubisch et al., 1999
DFNA2B GJB3 Xia et al., 1998
DFNA2C IFNLR1 Gao et al., 2017
DFNA3A GJB2 Kelsell et al., 1997
DFNA3B GJB6 Grifa et al., 1999
DFNA4A MYH14 Donaudy et al., 2004
DFNA4B CEACAM16 Zheng et al., 2011
DFNA5 GSDME/DFNA5 Van Laer et al., 1998
DFNA6/14/38 WFS1 Bespalova et al., 2001; Young et al., 2001
DFNA7 LMX1A Wesdorp et al., 2018
DFNA8/12 TECTA Verhoeven et al., 1998
DFNA9 COCH Robertson et al., 1998
DFNA10 EYA4 Wayne et al., 2001
DFNA11 MYO7A Liu et al., 1997
DFNA13 COL11A2 McGuirt et al., 1999
DFNA15 POU4F3 Vahava et al., 1998
DFNA17 MYH9 Lalwani et al., 2000
DFNA20/26 ACTG1 Zhu et al., 2003; van Wijk et al., 2003
DFNA22 MYO6 Melchionda et al., 2001
DFNA23 SIX1 Mosrati et al., 2011
DFNA25 SLC17A8 Ruel et al., 2008
DFNA27 REST Nakano et al., 2018
DFNA28 GRHL2 Peters et al., 2002
DFNA34 NLRP3 Nakanishi et al., 2017
DFNA36 TMC1 Kurima et al., 2002
DFNA37 COL11A1 Booth et al., 2018
DFNA40 CRYM Abe et al., 2003
DFNA41 P2RX2 Yan et al., 2013
DFNA44 CCDC50 Modamio-Hoybjor et al., 2007
DFNA50 MIRN96 Mencia et al., 2009
DFNA51 TJP2 Walsh et al., 2010
DFNA56 TNC Zhao et al., 2013
DFNA64 SMAC/DIABLO Cheng et al., 2011
DFNA65 TBC1D24 Azaiez et al., 2014; Zhang et al., 2014
DFNA66 CD164 Nyegaard et al., 2015
DFNA67 OSBPL2 Xing et al., 2014; Thoenes et al., 2015
DFNA68 HOMER2 Azaiez et al., 2015
DFNA69 KITLG Zazo Seco et al., 2015
DFNA70 MCM2 Gao et al., 2015
DFNA73 PTPRQ Eisenberger et al., 2017
  DMXL2 Chen et al., 2016
  MYO3A Grati et al., 2016
  PDE1C Wang et al., 2018
  TRRAP Xia et al., 2019
  PLS1 Morgan et al., 2019
  ATP2B2 Smits et al., 2019
  SCD5 Lu et al., 2020
DFNA78 SLC12A2 Mutai et al., 2020
  MAP1B Cui et al., 2020
  RIPOR2/FAM65B de Bruijn et al., 2020

 

Autosomal Dominant Genes Called in to Question

Locus (OMIM) Gene (OMIM) Original Reference Reference in Disagreement
DFNA48 MYO1A Donaudy et al., 2003 Eisenberger et al., 2014