Waardenburg Syndrome
The clinical symptoms of Waardenburg Syndrome (WS) include:
  • Dystopia canthorum (lateral displacement of the inner canthus of each eye)
  • Pigmentary abnormalities of hair, iris, and skin (often white forelock and heterochromia iridis)
  • Sensorineural deafness

Some symptoms may be absent.
WS is subdivided in two types (I and II) on the basis of dystopia canthorum.
The combination of WS type I characteristics with upper limb abnormalities has been called Klein-Waardenburg syndrome or WS type III.
The combination of recessively inherited WS type II characteristics with Hirschsprung disease has been called Waardenburg-Shah syndrome or WS type IV.