The clinical symptoms of Waardenburg Syndrome (WS) include:
Dystopia canthorum (lateral displacement of the inner canthus of each eye)
Pigmentary abnormalities of hair, iris, and skin (often white forelock and heterochromia iridis)
Some symptoms may be absent.
WS is subdivided in two types (I and II) on the basis of dystopia canthorum.
The combination of WS type I characteristics with upper limb abnormalities has been called Klein-Waardenburg syndrome or WS type III.
The combination of recessively inherited WS type II characteristics with Hirschsprung disease has been called Waardenburg-Shah syndrome or WS type IV.