Autosomal dominant

Locus (OMIM)

Location

Gene (OMIM)

Important reference

DFNA1

5q31

DIAPH1

Léon et al., 1992Lynch et al., 1997

DFNA2A

1p34

KCNQ4

Coucke et al., 1994Kubisch et al., 1999

DFNA2B 1p35.1 GJB3 Xia et al., 1999

DFNA3A

13q11-q12

GJB2

Chaib et al., 1994Denoyelle et al., 1998Kelsell et al., 1997

DFNA3B

13q12 GJB6 Grifa et al., 1999

DFNA4

19q13

MYH14

Chen et al., 1995Donaudy et al., 2004

DFNA4B 19q13.32 CEACAM16 Zheng et al., 2011

DFNA5

7p15

DFNA5

Van Camp et al., 1995Van Laer et al., 1998

DFNA6

4p16.3

WFS1

Lesperance et al., 1995Van Camp et al., 1999Bespalova et al., 2001Young et al., 2001

DFNA7

1q21-q23

unknown

Fagerheim et al., 1996

DFNA8

see DFNA12

 

 

DFNA9

14q12-q13

COCH

Manolis et al., 1996Robertson et al., 1998

DFNA10

6q22-q23

EYA4

O'Neill  et al., 1996Wayne et al., 2001

DFNA11

11q12.3-q21

MYO7A

Tamagawa et al., 1996,  Liu et al., 1997

DFNA12

11q22-24 

TECTA

Verhoeven et al., 1997Verhoeven et al., 1998

DFNA13

6p21

COL11A2

Brown et al., 1997McGuirt et al., 1999

DFNA14

see DFNA6

 

 

DFNA15

5q31

POU4F3

Vahava et al., 1998

DFNA16

2q24

unknown

Fukushima et al., 1999

DFNA17

22q

MYH9

Lalwani et al., 1999Lalwani et al., 2000

DFNA18

3q22

unknown

Bonsch et al., 2001

DFNA19

10 (pericentr.)

unknown

The Molecular Biology of Hearing and Deafness, Bethesda,October 8-11, 1998 (Green et al., abstract 107)

DFNA20

17q25

ACTG1

Morell et al., 2000, Yang et al., 2000Zhu et al., 2003, van Wijk et al., 2003, Kemperman et al., 2004

DFNA21

6p21

unknown

Kunst et al., 2000

DFNA22

6q13

MYO6

Melchionda et al., 2001

DFNA23

14q21-q22

SIX1

Salam et al., 2000Mosrati et al., 2011

DFNA24

4q

unknown

Hafner et al., 2000

DFNA25

12q21-24

SLC17A8

Greene et al., 1999, Ruel et al., 2008

DFNA26

see DFNA20

 

 

DFNA27

4q12

unknown

Fridell et al., 1999, Peters et al., 2008

DFNA28

8q22

GRHL2 

Anderson et al., 1999, Peters et al., 2002

DFNA30

15q25-26

unknown

Mangino et al., 2001

DFNA31

6p21.3

unknown

Snoeckx et al., 2004

DFNA32

11p15

unknown

Li et al., 2000

DFNA33

13q34-qter 

unknown 

Bonsch et al., 2009 

DFNA36

9q13-q21

TMC1

Kurima et al., 2002

DFNA38

see DFNA6

 

 

DFNA39  (see note 1)

4q21.3

DSPP

Xiao et al., 2001

DFNA41

12q24-qter

P2RX2

Blanton et al., 2002 Yan et al., 2013

DFNA42

5q31.1-q32

unknown

Xia et al., 2002

DFNA43

2p12

unknown  

Flex et al., 2003

DFNA44

3q28-29

CCDC50

Modamio-Hoybjor et al., 2003Modamio-Hoybjor et al., 2007

DFNA47

9p21-22

unknown

D'Adamo et al., 2003

DFNA48

12q13-q14

MYO1A

D'Adamo et al., 2003, Donaudy et al., 2003

DFNA49

1q21-q23

unknown

Moreno-Pelayo et al., 2003

DFNA50

7q32.2

MIRN96

Modamio-Hoybjor et al., 2004Mencia et al., 2009

DFNA51

9q21

TJP2

Walsh et al., 2010

DFNA52

4q28

unknown  

Xia et al., 2002 

DFNA53

14q11.2-q12

unknown

Yan et al., 2005

DFNA54

5q31

unknown

Gurtler et al., 2004

DFNA56 9q31.3-q34.3 TNC Zhao et al., 2013

DFNA57

19p13.2

unknown

Bonsch et al., 2008

DFNA58

2p12-p21

unknown

Lezirovitz et al., 2009

DFNA59

11p14.2-q12.3

unknown

Chatterjee et al., 2009

DFNA60 2q21.3-q24.1
Liu XZ et al. ARO meeting. Denver, February 2007.
DFNA64 12q24.31-q24.32 SMAC/DIABLO Cheng et al., 2011
DFNA65 16p13.3 TBC1D24 Azaiez et al., 2014; Zhang et al., 2014
DFNA66 6q15-21 CD164 Nyegaard et al., 2015
DFNA67 20q13.33 OSBPL2 Xing et al., 2015; Thoenes et al., 2015

12q21.32-q23.1 KITLG Zazo Seco et al., 2015




 

 

 


Note 1. This is not a nonsyndromic form of hearing impairment, but dentinogenesis imperfecta, associated with hearing impairment in some families.